Regulation of mRNA translation in renal physiology and 1 disease 2 3 4 5 6 7
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10 11 12 13 14 15 16 17 18 Running title: mRNA translation regulation 19 20 21 22 23 24 25 Address correspondence to: B. S. Kasinath, MD 26 Division of Nephrology, Dept of Medicine 27 University of Texas Health Science Center 28 7703, Floyd Curl Drive 29 San Antonio TX 78229-3900 30 Phone: 210-567-4707 31 Fax: 210-567-4712 32 Email: [email protected] 33 34 Articles in PresS. Am J Physiol Renal Physiol (June 17, 2009). doi:10.1152/ajprenal.90748.2008
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Translation, a process of generating a peptide from the codons present in messenger RNA, can be a site of independent regulation of protein synthesis; it has not been well studied in the kidney. Translation occurs in three stages (initiation, elongation, and termination), each with its own set of regulatory factors. Mechanisms controlling translation include small inhibitory RNAs such as microR...
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